Current study was undertaken to improve the solubility of glibenclamide, a poorly water soluble drug. Physical mixtures, kneading mixtures or solid dispersions were prepared using shatavari as solubility enhancer at 1:1, 1:3, 1:5, 1:7 & 1:9 drug to carrier weight ratio. The resulting systems were subjected to solubility analysis and in vitro dissolution studies. X-ray diffraction, Infrared Fourier Transform Spectroscopy (FTIR) and differential scanning calorimetry were used to characterize the resulting systems. The solid dispersions of glibenclamide with drug carrier ratio at 1:9 showed superior dissolution rate of 46.05 % when compared with pure drug (3.27 %). This impressive improvement in dissolution is attributed to lower energy required for the dissolution due to amorphous form of the drug, glibenclamide.
Loading....